This study investigates the expression and genetic polymorphism of KLF14 and SR-B1 genes in cholesterol gallstone patients, finding associations with blood lipid levels, gender, and environmental factors.

medRxiv · Aug 13, 2025 · PreprintGenetic & Genomic Medicine

Transcriptomic encoding of sensorimotor transformation in the midbrain

Zhiyong Xie, Mengdi Wang, Zeyuan Liu, Congping Shang, Changjiang Zhang, Le Sun, Huating Gu, Gengxin Ran, Qing Pei, Qiang Ma, Meizhu Huang, Junjing Zhang, Rui Lin, Youtong Zhou, Jiyao Zhang, , Xiaoqun Wang

The paper identifies molecularly distinct neuronal subtypes in the superior colliculus that mediate predator avoidance and prey capture behaviors through separate transcriptomic codes.

eLife · Jul 28, 2021Peer-reviewedNeuroscience

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

Xianwen Ren, Wen Wen, Xiaoying Fan, Wenhong Hou, Bin Su, Pengfei Cai, Jiesheng Li, Yang Liu, Fei Tang, Fan Zhang, Yu Yang, Jiangping He, Wenji Ma, Jingjing He, Pingping Wang, , Zemin Zhang

This study uses single-cell RNA sequencing to analyze immune responses in COVID-19 patients, identifying key immune cell changes and molecular pathways linked to disease severity.

bioRxiv · Oct 29, 2020 · PreprintGenomics

A single-cell transcriptome atlas of the aging human and macaque retina

Wenyang Yi, Yufeng Lu, Suijuan Zhong, Mei Zhang, Le Sun, Hao Dong, Mengdi Wang, Min Wei, Haohuan Xie, Hongqiang Qu, Rongmei Peng, Jing Hong, Ziqin Yao, Yunyun Tong, Wei Wang, , Tian Xue

This study creates a single-cell transcriptome atlas of human and macaque retinas across ages, revealing species-specific molecular features and age-related changes in cell types and disease associations.

National Science Review · Aug 8, 2020Peer-reviewedNeuroscience