BioengineeringbioRxivPreprint
Designed allosteric biosensors for engineered T cell therapy of cancer
Jan A. Rath, Lucas S. P. Rudden, Nazila Nouraee…·Caroline Arber
This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.
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