Jan A. Rath

This study uses cryo-expansion microscopy to visualize the nanoscale architecture of immune synapses in T cells and their interactions with tumor cells, revealing structural details of signaling molecules and lytic granules.

This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.