Knockout of circRNAs by base editing back-splice sites of circularized exons
Xiang Gao, Xu-Kai Ma, Xiang Li, Guo‐Wei Li, Chu‐Xiao Liu, Jun Zhang, Ying Wang, Jia Wei, Jia Chen, Ling‐Ling Chen, Li Chun Yang
This study uses base editors to specifically knock out circRNAs by targeting back-splice sites, showing efficient repression of circular RNAs without affecting linear cognate RNAs.
Genome biology · Jan 10, 2022Peer-reviewedBioinformatics