Circular RNA aptamers ameliorate AD-relevant phenotypes by targeting PKR
Xin Feng, Bowen Jiang, Si-Nan Zhai…·Ling‐Ling Chen
The paper shows that circular RNAs targeting PKR reduce neuroinflammation and amyloid-beta plaques in AD mouse models.
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Center for Excellence in Molecular Cell ScienceORCID 0000-0002-6725-8327Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Xin Feng, Bowen Jiang, Si-Nan Zhai…·Ling‐Ling Chen
The paper shows that circular RNAs targeting PKR reduce neuroinflammation and amyloid-beta plaques in AD mouse models.
Xiang Gao, Xu-Kai Ma, Xiang Li…·Li Chun Yang
This study uses base editors to specifically knock out circRNAs by targeting back-splice sites, showing efficient repression of circular RNAs without affecting linear cognate RNAs.
Guo‐Wei Li, Nan Fang, Guo-Hua Yuan…·Li Chun Yang
SCAPTURE identifies and quantifies cleavage and polyadenylation sites from 3' tag-based scRNA-seq, improving cell identity refinement.
Xu-Kai Ma, Mengran Wang, Chu‐Xiao Liu…·Li Chun Yang
The paper introduces CLEAR, a pipeline to compare circular and linear RNA expression using RNA-seq data by calculating CIRCscore.