Ling‐Ling Chen

abcFISH enables multiplexed, single-molecule imaging of circRNA spatial heterogeneity, revealing cell-type-specific expression and functional interactions.

The paper investigates how MDA5 CARDs assemble and interact with LGP2 through one-dimensional movement along dsRNA to regulate immune response.

This study maps the spatiotemporal distribution of pre-rRNA intermediates in the human nucleolus, revealing structural and functional differences between amniote and anamniote nucleoli.

The paper shows that circular RNAs targeting PKR reduce neuroinflammation and amyloid-beta plaques in AD mouse models.

This study uses base editors to specifically knock out circRNAs by targeting back-splice sites, showing efficient repression of circular RNAs without affecting linear cognate RNAs.

SCAPTURE identifies and quantifies cleavage and polyadenylation sites from 3' tag-based scRNA-seq, improving cell identity refinement.

This study uses CRISPR-Cas13 to functionally screen circRNAs, identifying roles in cell growth and development.

The paper introduces CLEAR, a pipeline to compare circular and linear RNA expression using RNA-seq data by calculating CIRCscore.