Li Chun Yang

abcFISH enables multiplexed, single-molecule imaging of circRNA spatial heterogeneity, revealing cell-type-specific expression and functional interactions.

This study maps the spatiotemporal distribution of pre-rRNA intermediates in the human nucleolus, revealing structural and functional differences between amniote and anamniote nucleoli.

The paper shows that circular RNAs targeting PKR reduce neuroinflammation and amyloid-beta plaques in AD mouse models.

The paper introduces LINEMAP, a computational framework that traces and maps mutation networks in single-cell lineage dynamics using homing CRISPR technology.

DEMINING detects DNA and RNA mutations in RNA-seq data using DeepDDR, revealing new mutations in leukemia and non-primate species via transfer learning.

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

This paper develops an allele-specific gene editing approach to target the T17M RHO mutant allele in retinitis pigmentosa, showing improved retinal function and photoreceptor preservation in mice.

RNAlight identifies nucleotide features determining RNA subcellular localization using LightGBM and Tree SHAP, revealing sequence basis for distinct RNA localization patterns.

This study uses base editors to specifically knock out circRNAs by targeting back-splice sites, showing efficient repression of circular RNAs without affecting linear cognate RNAs.

SCAPTURE identifies and quantifies cleavage and polyadenylation sites from 3' tag-based scRNA-seq, improving cell identity refinement.

This study uses CRISPR-Cas13 to functionally screen circRNAs, identifying roles in cell growth and development.

The paper investigates the relationship between m5C modification in mRNA and translation by analyzing polysome profiles and validating m5C sites across different cell lines.

The paper introduces CLEAR, a pipeline to compare circular and linear RNA expression using RNA-seq data by calculating CIRCscore.

This study shows morphine selectively enhances glutamate release from mPFC to VTA DA neuron terminals, but not from BLA or LH, and this effect reduces morphine-induced locomotor activity.