This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

DOI 10.64898/2026.01.06.697917

mousebulk RNA-seq

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Molecular BiologyNature MethodsPeer-reviewedDec 7, 2020

Screening for functional circular RNAs using the CRISPR-Cas13 system

Siqi Li, Xiang Li, Wei Xue…·Ling‐Ling Chen

This study uses CRISPR-Cas13 to functionally screen circRNAs, identifying roles in cell growth and development.

357 citationstop 1%

humanmouse

𝕏 PostBluesky

Developmental BiologybioRxivPreprintApr 8, 2019

Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analyses

Xue Wang, Haibo Xu, Chaping Cheng…·Helen He Zhu

The paper identifies a basal stem cell subpopulation in the prostate using lineage tracing, functional analysis, and single-cell RNA-seq, showing Zeb1+ cells are multipotent prostate basal stem cells.

2 citations

mousescRNA-seq

𝕏 PostBluesky

Developmental BiologyPLoS GeneticsPeer-reviewedAug 17, 2018

E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo

Xue Wang, Kai Zhang, Zhongzhong Ji…·Helen He Zhu

This study shows that E-cadherin connects cell polarity and spindle orientation in prostate epithelial cells, preventing carcinogenesis.

66 citationstop 5%

mouseexperimental assay

𝕏 PostBluesky