Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?
Lydia L. Shook, Evan A. Bordt, Marie-Charlotte Meinsohn, David Pépin, Rose M. De Guzman, Sara M. Brigida, Laura J. Yockey, Kaitlyn E. James, Mackenzie W. Sullivan, Lisa M. Bebell, Drucilla Jane Roberts, Anjali J. Kaimal, Jonathan Z. Li, Danny Joseph Schust, Kathryn J. Gray, Andrea G. Edlow
The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.
bioRxiv · Apr 1, 2021 · PreprintDevelopmental Biology