Evan A. Bordt

This study shows that TLR4 signaling in CX3CR1-expressing myeloid cells affects microglial morphology, synaptic engulfment, and communicative behaviors in mice under normal conditions.

CRABS-ROC, a respirometry protocol, overcomes substrate limitations to reveal excess mitochondrial Complex I capacity in neurons and detect hidden Complex I deficits in mutant mitochondria.

This study shows that juvenile mice retain strong maternal preference post-weaning, which remains resilient to immune activation, with sex-specific differences in exploration behavior.

The paper shows that Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity, suggesting Hofbauer cells as a noninvasive biomarker for fetal microglial programming.

This study shows that male-biased social behavior deficits after early-life immune activation are linked to microglial mitochondrial dysfunction and are influenced by perinatal gonadal hormones.

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.

This study shows that reducing tau with a degrader prevents mitochondrial fragmentation and oxidative stress in ALS models.

The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.