Andrea G. Edlow

The paper shows that Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity, suggesting Hofbauer cells as a noninvasive biomarker for fetal microglial programming.

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.

The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.

This study generates patient-derived microglia-like cells from umbilical cord blood to model fetal brain immune responses to maternal SARS-CoV-2 exposure.