The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.

bioRxiv · Apr 1, 2021 · PreprintDevelopmental Biology

Umbilical cord blood derived microglia-like cells to model COVID-19 exposure

Steven D. Sheridan, Jessica M. Thanos, Rose M. De Guzman, Liam T. McCrea, Joy E. Horng, Ting Fu, Carl M. Sellgren, Roy H. Perlis, Andrea G. Edlow

This study generates patient-derived microglia-like cells from umbilical cord blood to model fetal brain immune responses to maternal SARS-CoV-2 exposure.

Translational Psychiatry · Mar 19, 2021Peer-reviewedNeuroscience

Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1

John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rose M. De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander T. Khmaladze, Alexey V. Semyanov, , Annalisa Scimemi

The paper shows circadian rhythms in hippocampal CA1 neurons and astrocytes affect synaptic plasticity through changes in NMDA receptor expression and astrocytic proximity to synapses, altering glutamate clearance and cognitive processing.

Cell Reports · Oct 1, 2020Peer-reviewedNeuroscience