David Pépin

This study identifies cancer-associated mesothelial cells (CAMCs) as drivers of immune escape and therapy resistance in ovarian cancer by altering immune cell infiltration and function.

This study identifies FSTL3 as a biomarker of poor prognosis and immunotherapy resistance in ovarian cancer, showing its role in promoting a mesenchymal phenotype and immunosuppressive microenvironment.

This study identifies miR-193b-3p downregulation via the ERK/EZH2/DNMT1 axis in ovarian cancer metastasis initiating cells, showing its role in promoting cancer stem cell properties and invasion.

This study uses scRNA-seq to investigate how AMH protects ovarian cells from doxorubicin toxicity by modulating cell fate and DNA repair mechanisms in different ovarian cell types.

This study reveals the structural basis of AMH procomplex signaling, showing how the prodomain maintains activity through a unique conformational mechanism.

This study constructs a single-cell atlas of the murine ovary by analyzing >34,000 cells across the estrous cycle to characterize cell state dynamics and transcriptional changes.

The paper examines placental ACE2 and TMPRSS2 expression in relation to maternal SARS-CoV-2 infection and fetal sex, finding sexually dimorphic effects on TMPRSS2 but not ACE2.