Cx3cr1-BAC-CRE-mediated knockout of toll-like receptor 4 alters mouse communicative behaviors, microglial morphology, and engulfment of synaptic material
Izabella M. Bankowski, Indra R. Bishnoi, Eva E. Shin, Mia J Cashin, Dorit Möhrle, Haley A. Norris, Drew T Barry, Maggie M. Slamin, Evan A. Bordt
This study shows that TLR4 signaling in CX3CR1-expressing myeloid cells affects microglial morphology, synaptic engulfment, and communicative behaviors in mice under normal conditions.
bioRxiv · Sep 23, 2026 · PreprintNeuroscience