Alexis M. Ceasrine

The paper shows that Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity, suggesting Hofbauer cells as a noninvasive biomarker for fetal microglial programming.

This study identifies IL34 as a neuron-derived cytokine that regulates microglia maturation and synapse engulfment in the developing mouse cortex.

The paper shows maternal high-fat diet affects placenta-brain communication differently in male and female offspring, leading to sex-specific behavioral and serotonin-related changes.

This study shows that male-biased social behavior deficits after early-life immune activation are linked to microglial mitochondrial dysfunction and are influenced by perinatal gonadal hormones.

This study shows that prenatal exposure to environmental toxins and stress impairs microglial function and leads to behavioral issues in male mice.

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.