William A. Carlezon

Stressor Identity Shapes Reactivity To Subsequent Stress

This study shows that different types of acute stressors affect future fear learning differently in mice, with shock and social defeat enhancing fear memory recall, while restraint stress does not.

Stress-induced adaptations in nucleus accumbens dopamine D1 receptor-expressing cells correspond to social avoidance behavior in male mice

The paper links stress-induced increases in D1R-associated dynorphin signaling in the nucleus accumbens to social avoidance behavior in male mice.

Fine mapping of PTSD GWAS reveals a role for amygdala Foxp2 in regulation of fear and threat responses

This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.

A critical role for the anterior insula in impaired adult social interaction after early life maltreatment.

This study identifies the anterior insula as a key circuit affected by early life maltreatment, showing its role in male social avoidance in adulthood.

Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally

This study shows that early life stress in mice leads to social behavior deficits and altered stress biomarkers in adolescence, with effects persisting across generations.

Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress

This study examines the relationship between sleep patterns and anhedonia in male mice exposed to early-life stress, finding significant correlations between sleep architecture and anhedonic phenotypes.

Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture

This study shows that inflammatory pain in mice alters sleep architecture and circadian rhythms, with effects dependent on the light cycle.

Intra-amygdala circuits of sleep disruption-induced anxiety in female mice

This study investigates how sleep disruption affects anxiety-related circuits in female mice by examining synaptic changes in BLA to CRF-CeL projections.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

Differential effects of the stress peptides PACAP and CRF on sleep architecture in mice

This study investigates how PACAP and CRF, two stress peptides, affect sleep architecture in mice, finding distinct impacts on sleep stages and behavior.

Acute sleep deprivation reduces fear memories in male and female mice

This study shows that sleep deprivation after fear conditioning reduces fear memories in mice, possibly through BDNF-mediated neuroadaptations in the amygdala.

Spontaneous oxycodone withdrawal disrupts sleep, circadian, and electrophysiological dynamics in rats

This study examines how spontaneous oxycodone withdrawal affects sleep, circadian rhythms, and EEG dynamics in rats over time.

Early life stress in male mice blunts responsiveness in a translationally-relevant reward task

This study shows that early-life stress in male mice reduces response bias for highly rewarded stimuli in a translational reward task, suggesting potential parallels with human depression.

Impact of social dominance hierarchy on PACAP expression in the extended amygdala, corticosterone, and behavior in C57BL/6 male mice

This study examines how social dominance rank in mice affects PACAP expression, corticosterone levels, and behavior, finding higher PACAP in subordinates and lower corticosterone in subordinates.

PACAP-mediated gating of anxiety-controlling circuits

This study shows PACAP modulates anxiety circuits by altering synaptic efficacy in BLA-ovBNST-adBNST pathways, leading to inhibition of adBNST and increased anxiety.

Gonadal Hormones Impart Male-Biased Behavioral Vulnerabilities to Immune Activation via Microglial Mitochondrial Function

This study shows that male-biased social behavior deficits after early-life immune activation are linked to microglial mitochondrial dysfunction and are influenced by perinatal gonadal hormones.

Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice

This study examines how Hnrnph1 mutant mice respond to methamphetamine in terms of reward sensitivity and behavior.