Molecular BiologyNature CommunicationsPeer-reviewed
A GABARAP-PtdIns3K-C1 positive feedback loop at the heart of the phagophore nucleation
Antoine Nicolas Dessus, Yohei Ohashi, Maxime Bourguet…·Roger Lee Williams
The paper identifies a positive feedback loop between GABARAP and PtdIns3K-C1 that drives PtdIns3P production, essential for autophagosome biogenesis.
DOI 10.1038/s41467-026-76135-w