Nicholas T. Ktistakis

The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.

The paper identifies a positive feedback loop between GABARAP and PtdIns3K-C1 that drives PtdIns3P production, essential for autophagosome biogenesis.

This study uses live imaging and mathematical modeling to analyze ATG13 dynamics in non-selective autophagy and mitophagy, revealing distinct patterns of translocation and their relationship to mitochondrial fragment size.