Sebastian Hutchinson

The paper identifies a variant rRNA in Plasmodium falciparum that represses translation during host-to-vector transmission by forming a dominant-negative ribosome.

The paper shows that VSG transcripts play a non-coding role in allelic exclusion in trypanosomes by participating in allelic competition.

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

This paper introduces a method to parallelize single-molecule binding kinetic measurements using protein barcode sequencing, enabling rapid and multiplexed screening of protein libraries.

This study develops a protein barcoding workflow with single-molecule Next-Generation Protein Sequencing to enable multiplexed protein analysis and tracking.

This study uses scRNA-seq to analyze Trypanosoma brucei development in tsetse fly salivary glands, revealing dynamic VSG gene activation and monoallelic expression establishment.

The paper identifies a novel mechanism in trypanosomes where inter-chromosomal interactions between an antigen coding gene and an mRNA splicing locus ensure monogenic antigen expression.

This study shows RAD50 promotes homologous recombination and limits antigenic variation in Trypanosoma brucei by controlling DNA repair mechanisms.

The paper identifies biallelic LRRC56 mutations causing ciliary dysfunction and laterality defects in two families, linking LRRC56 to intraflagellar transport and dynein arm assembly.