Author

Enbo Chen

Peking UniversityORCID 0000-0002-2294-9415Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CUT&Tag· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Shuwen ZhangiD· 2 shared Youdong Jack MaoiD· 2 shared C Liu· 1 shared Chang-Cheng Yin· 1 shared Daniel J. FinleyiD· 1 shared Deyao YiniD· 1 shared Di WuiD· 1 shared Lihong ZhaoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Shuwen ZhangORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 11, 2026

UBE3C retrofits the proteasome to enforce degradation of ultra-stable folds

Shitao Zou, Deyao Yin, Miyun Shi…·Youdong Jack Mao

This study reveals how UBE3C reprograms the proteasome to degrade ultra-stable protein folds by bypassing USP14 and enhancing substrate unfolding.

DOI 10.64898/2026.02.24.707655

humanprotein structure

𝕏 PostBluesky

BioinformaticsInternational Journal of Molecular SciencesPeer-reviewedAug 9, 2022

Visualizing conformational space of functional biomolecular complexes by deep manifold learning

Zhaolong Wu, Enbo Chen, Shuwen Zhang…·Youdong Mao

This paper introduces AlphaCryo4D, a deep learning framework for atomic-level cryo-EM reconstructions of conformational continua in biomolecular complexes, demonstrating its ability to visualize dynamic components and hidden conformational space.

29 citations

CUT&Tagdeep learning

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