Zhaolong Wu

This paper identifies rapaprotin as a 26S proteasome assembly inhibitor that is activated by PREP to induce apoptosis and synergizes with proteasome inhibitors in cancer cells.

This paper introduces AlphaCryo4D, a deep learning framework for atomic-level cryo-EM reconstructions of conformational continua in biomolecular complexes, demonstrating its ability to visualize dynamic components and hidden conformational space.