Author

Shuwen Zhang

Peking UniversityORCID 0000-0002-5352-409XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:benchmarking· 1 Assay:CUT&Tag· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Youdong Jack MaoiD· 3 shared Deyao YiniD· 2 shared Enbo CheniD· 2 shared Shitao ZouiD· 2 shared Zhaolong WuiD· 2 shared A. V. Subba Rao· 1 shared Brett R. Ullman· 1 shared C Liu· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

Youdong Jack MaoORCID

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3 papers

Recent·Most cited

UBE3C retrofits the proteasome to enforce degradation of ultra-stable folds

Shitao Zou, Deyao Yin, Miyun Shi, Enbo Chen, Xin Luo, M.R. Baird, Lihong Zhao, Shuo Cao, Di Wu, Shuwen Zhang, Daniel J. Finley, Youdong Jack Mao

This study reveals how UBE3C reprograms the proteasome to degrade ultra-stable protein folds by bypassing USP14 and enhancing substrate unfolding.

bioRxiv · Mar 11, 2026 · PreprintBiochemistry

Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome

Hanjing Peng, Zufeng Guo, Wei Li Wang, Deyao Yin, Shitao Zou, Thomas Asbell, Brett R. Ullman, Maya Thakar, Feiran Zhang, Sam Y. Hong, A. V. Subba Rao, Kunyu Wang, Shuwen Zhang, Zhaolong Wu, Xuemei Li, , Jun O. Liu

This paper identifies rapaprotin as a 26S proteasome assembly inhibitor that is activated by PREP to induce apoptosis and synergizes with proteasome inhibitors in cancer cells.

bioRxiv · Feb 21, 2025 · PreprintPharmacology & Toxicology

Visualizing conformational space of functional biomolecular complexes by deep manifold learning

Zhaolong Wu, Enbo Chen, Shuwen Zhang, Yinping Ma, C Liu, Chang-Cheng Yin, Youdong Mao

This paper introduces AlphaCryo4D, a deep learning framework for atomic-level cryo-EM reconstructions of conformational continua in biomolecular complexes, demonstrating its ability to visualize dynamic components and hidden conformational space.

International Journal of Molecular Sciences · Aug 9, 2022Peer-reviewedBioinformatics