Author

Anne Ast

Max Delbrück CenterORCID 0000-0002-2312-1257Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

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Andranik IvanoviD· 1 shared Astrid G. PetzoldtiD· 1 shared Christian Haenig· 1 shared Claudia Langnick· 1 shared Dieter BeuleiD· 1 shared Elisabeth GeorgiiiD· 1 shared Erich E. WankeriD· 1 shared Franziska SchindleriD· 1 shared

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1 shared paperMolecular Biology

Andranik IvanovORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 6, 2025

Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked

Anne Ast, Leonard Roth, Lydia Brusendorf…·Erich E. Wanker

This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.

DOI 10.1101/2025.02.06.636778

Drosophilaproteomics

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