Molecular BiologybioRxivPreprint
Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked
Anne Ast, Leonard Roth, Lydia Brusendorf…·Erich E. Wanker
This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.
DOI 10.1101/2025.02.06.636778