Author

Leonard Roth

Max Delbrück Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Andranik IvanoviD· 2 shared Christian Haenig· 2 shared Erich E. WankeriD· 2 shared Franziska SchindleriD· 2 shared Oliver PoppiD· 2 shared Orchid AmmariD· 2 shared Philipp MertinsiD· 2 shared Anne AstiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Andranik IvanovORCID

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Author profile →

2 papers

Recent·Most cited

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig, Philipp Trepte, Orchid Ammar, Christopher Secker, Oliver Popp, Andranik Ivanov, Brandon A. Keith, Rachel J. Harding, Franziska Schindler, Tomáš Koudelka, Leonard Roth, Nadine Scharek, Martina Zenkner, , Erich E. Wanker

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

bioRxiv · Apr 1, 2026 · PreprintCell Biology

Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked

Anne Ast, Leonard Roth, Lydia Brusendorf, Franziska Schindler, Orchid Ammar, Sofie Berberich, Juliane Edel, Megan Bonsor, Elisabeth Georgii, Christian Haenig, Claudia Langnick, Andranik Ivanov, Dieter Beule, Marie Piraud, Séverine Kunz, , Erich E. Wanker

This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.

bioRxiv · Feb 6, 2025 · PreprintMolecular Biology