Author

Youssef Arafat

City St George's, University of LondonORCID 0000-0002-2318-6763Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Constantino Carlos Reyes‐AldasoroiD· 2 shared Esther CastellanoiD· 2 shared Alejandro RoselliD· 1 shared Belén Martínez-CastedoiD· 1 shared Charles SwantoniD· 1 shared Cristina CuestaiD· 1 shared Cristina Cuesta-Apausa· 1 shared Diana Loa-Mesón· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Constantino Carlos Reyes‐AldasoroORCID

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2 papers

Recent·Most cited

Fibre tracing in biomedical images: An objective comparison between seven algorithms

Youssef Arafat, Cristina Cuesta-Apausa, Esther Castellano, Constantino Carlos Reyes‐Aldasoro

This paper compares seven algorithms for fibre tracing in biomedical images, finding that Trace Ridges performs best in total distance error while being fast.

PLoS ONE · Apr 10, 2025Peer-reviewedCancer Biology

RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program

Cristina Cuesta, Marta Alcón Pérez, Rosa Ramírez Cota, Sara Coadour, Jie Zheng, Nicole Procel, Dirk Fennema Galparsoro, Alejandro Rosell, Diana Loa-Mesón, Belén Martínez-Castedo, Youssef Arafat, Héctor Sanz-Fraile, Vinothini Rajeeve, Diego Alonso‐López, Robert E. Hynds, , Esther Castellano

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.

bioRxiv · Jan 20, 2025 · PreprintCancer Biology