This paper compares seven algorithms for fibre tracing in biomedical images, finding that Trace Ridges performs best in total distance error while being fast.

PLoS ONE · Apr 10, 2025Peer-reviewedCancer Biology

Pharmacological SOS1 inhibitor BI-3406 demonstrates in vivo anti-tumor activity comparable to SOS1 genetic ablation in KRAS mutant tumors

Fernando C. Baltanás, Maximilian Kramer‐Drauberg, Rósula García‐Navas, Enrico Patrucco, Ettore Petrini, Heribert Arnhof, Andrea Olarte-San Juan, Pablo Rodríguez-Ramos, Javier Borrajo-Sánchez, Nuria Calzada, Esther Castellano, Barbara Mair, Kaja Kostyrko, Marco H. Hofmann, Chiara Ambrogio, Eugenio Santos

This study shows that the SOS1 inhibitor BI-3406 effectively reduces tumor growth in KRAS mutant cancers, similar to genetic SOS1 ablation, with comparable efficacy to another KRAS inhibitor.

Proceedings of the National Academy of Sciences · Mar 12, 2025Peer-reviewedCancer Biology

RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program

Cristina Cuesta, Marta Alcón Pérez, Rosa Ramírez Cota, Sara Coadour, Jie Zheng, Nicole Procel, Dirk Fennema Galparsoro, Alejandro Rosell, Diana Loa-Mesón, Belén Martínez-Castedo, Youssef Arafat, Héctor Sanz-Fraile, Vinothini Rajeeve, Diego Alonso‐López, Robert E. Hynds, , Esther Castellano

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.

bioRxiv · Jan 20, 2025 · PreprintCancer Biology