RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program
Cristina Cuesta, Marta Alcón Pérez, Rosa Ramírez Cota, Sara Coadour, Jie Zheng, Nicole Procel, Dirk Fennema Galparsoro, Alejandro Rosell, Diana Loa-Mesón, Belén Martínez-Castedo, Youssef Arafat, Héctor Sanz-Fraile, Vinothini Rajeeve, Diego Alonso‐López, Robert E. Hynds, , Esther Castellano
This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.
bioRxiv · Jan 20, 2025 · PreprintCancer Biology