Julie A. Theriot

The paper uses ML to analyze morphological dynamics of hiPSC-derived endothelial cells under shear stress, identifying a bifurcation between two stable cell states.

The paper investigates the role of intracellular pH dynamics in zebrafish larval tail regeneration, finding that pH changes are critical for cell proliferation and tissue repair.

The paper presents a hiPS cell model to study EMTs by comparing 2D and 3D cultures, measuring changes in cell function, markers, organization, and environment.

A CRISPRi migration screen in neutrophil-like HL-60 cells identified Galvanin (TMEM154), a single-pass membrane protein whose negatively charged ectodomain electrophoreses anodally to steer cathodal electrotaxis.

This paper introduces a morphology-appropriate representation learning framework for 3D multi-piece intracellular structures, showing improved sub-cluster discovery and phenotypic profiling.

The paper analyzes nuclear growth variations in hiPS cell colonies, finding context-dependent and inherited mechanisms shaping growth trajectories.

The paper develops a model to explain how single cells respond to electric fields, showing that diffusion of membrane proteins and orientation dynamics are key factors in galvanotaxis.

This study shows that Listeria monocytogenes uses cell-to-cell spread to bypass nutrient limitation in host cells, allowing continuous replication and avoiding stationary phase.

The paper develops a hybrid agent-based model to simulate hiPS cell colony dynamics, identifies limitations of the CPM approach, and suggests improvements for accurate simulations.

The paper quantifies the relationship between bacterial growth rate, cell size, and protein content in E. coli using proteomic data, finding ribosome biogenesis as a primary determinant of growth rate.

The paper compares different computational methods for simulating cellular biochemistry and identifies discrepancies in results, emphasizing the need for critical evaluation of models.