Edith M. Hessel

Rosalind, a DNA foundation model, predicts variant-gene regulatory relationships without proximity bias, identifying distal genes as more impactful in osteoporosis.

This paper develops a CRISPR-based therapy targeting Shiga toxin genes in STEC infections, showing efficacy in reducing bacterial load and mitigating disease in animal models.

This paper develops a method to edit bacterial genes in the gut using a phage-derived particle, achieving high editing efficiency and stable maintenance of modified bacteria.

This study uses genome editing to show that FOXJ1 is essential for ciliation in human airway epithelial cells.