Author

Jörg Hamann

Netherlands Institute for NeuroscienceORCID 0000-0002-9448-1727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Joost SmoldersiD· 3 shared Aletta M.R. van den BoschiD· 2 shared Hendrik J. EngelenburgiD· 2 shared Inge HuitingaiD· 2 shared Aldo JongejaniD· 1 shared Anna LasneiD· 1 shared Anneleen M. BobeldijkiD· 1 shared Bart J. L. EggeniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Joost SmoldersORCID

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3 papers

Recent·Most cited

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive Disease

Juan Villar-Vesga, Pauline Clément, Hannah Van Hove, Elèni Meuffels, Viola Bugada, Jeanne Kim, Deborah Greis, Pau Jorba-Adolff, Maud Mayoux, Anna Lasne, Christian Ashworth, Pascale Zwicky, Stefanie Schärli, Hendrik J. Engelenburg, Cheng‐Chih Hsiao, , Sarah Mundt

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

bioRxiv · Aug 15, 2025 · PreprintImmunology

Microglial states determine lesion dynamics in multiple sclerosis

Aletta M.R. van den Bosch, Jia Hui Khoo, Zhigang Lu, Liang Han, Dennis D. Wever, Li Pu, Bart J. L. Eggen, Mathias Uhlén, Joost Smolders, Jörg Hamann, Zhouchun Shang, Jan Mulder, Inge Huitinga

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

bioRxiv · Oct 25, 2024 · PreprintNeuroscience

Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

Aletta M.R. van den Bosch, Marlijn van der Poel, Nina L. Fransen, Maria C. J. Vincenten, Anneleen M. Bobeldijk, Aldo Jongejan, Hendrik J. Engelenburg, Perry D. Moerland, Joost Smolders, Inge Huitinga, Jörg Hamann

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

Nature Communications · Feb 23, 2024Peer-reviewedNeuroscience