William F. Beckman

Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific

The paper shows ASCL1 controls distinct transcriptional programs in different cell cycle stages by binding chromatin at promoters and enhancers, with G1 arrest required for neuronal differentiation.

4sUDRB-sequencing for genome-wide transcription bursting quantification in breast cancer cells

This study quantifies transcription bursting genome-wide in breast cancer cells using 4sUDRB-sequencing and finds burst sizes up to 160 transcripts, with correlations to promoter features and drug response.