Synthetic BiologybioRxivPreprint
Evolution Inspired Engineering of Megasynthetases
Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler…·Helge B. Bode
The paper describes an evolution-inspired method to engineer NRPS by identifying a recombination breakpoint and using it to assemble NRPS fragments for producing a proteasome inhibitor.