Author

Sebastian Kaiser

Max Planck Institute for Terrestrial Microbiology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Helge B. BodeiD· 3 shared Georg K. A. HochbergiD· 2 shared Ali KhoshoueiiD· 1 shared Carsten Kegler· 1 shared Charles J. Buchanan· 1 shared Claire Lefèvre· 1 shared Daniel SchindleriD· 1 shared Daniela Vidaurre Barahona· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Helge B. BodeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acyl amides derived from a bacterial symbiont control development of its nematode host

Ли Су, Daniela Vidaurre‐Barahona, Michelle Anne Diano, Krishna Patel, Sebastian Kaiser, Kevin Hoffman, Edna Bode, Rogelio Hernández-Tamayo, Ali Khoshouei, Richard F. Collins, Martin R. Thanbichler, Jesko Koehnke, Helge B. Bode

The paper identifies bacterial acyl amides, called stripteamides, as signals controlling nematode development in the Steinernema-Xenorhabdus symbiosis.

bioRxiv · Jun 16, 2026 · PreprintMicrobiology

Drift, selection and convergence in the evolution of a nonribosomal peptide

Sebastian Kaiser, Niayesh Shahmohammadi, Trinetri S. M. Goel, Charles J. Buchanan, Sriram G. Garg, Daniela Vidaurre Barahona, Zhengyi Qian, Claire Lefèvre, Daniel Schindler, Yonggyun Kim, Helge B. Bode, Georg K. A. Hochberg

The paper studies the evolution of nonribosomal peptides in entomopathogenic bacteria, finding evidence of both neutral drift and natural selection driving structural convergence and toxicity diversification.

bioRxiv · Dec 16, 2025 · PreprintEvolutionary Biology

Evolution Inspired Engineering of Megasynthetases

Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler, Sebastian Kaiser, Yan‐Ni Shi, Wolfgang Kuttenlochner, Leonie Schenk, T. M. Mohiuddin, M. Groll, Georg K. A. Hochberg, Helge B. Bode

The paper describes an evolution-inspired method to engineer NRPS by identifying a recombination breakpoint and using it to assemble NRPS fragments for producing a proteasome inhibitor.

bioRxiv · Dec 2, 2022 · PreprintSynthetic Biology