Author

Carsten Kegler

Max Planck Institute for Terrestrial Microbiology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Approach:statistical model· 1

Frequent Co-Authors

Helge B. BodeiD· 3 shared Marie Selch TvilumiD· 2 shared Camilla Bak NielseniD· 1 shared Georg K. A. HochbergiD· 1 shared Jonas L Veiler· 1 shared Karsten SiemsiD· 1 shared Kenan A. J. BozhüyükiD· 1 shared Kevin Hoffmann· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Helge B. BodeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Heterologous Reconstitution of 4-Amidopentadienoate Biosynthesis Identifies the PKS Machinery Responsible for Warhead Formation

Marie Selch Tvilum, Jonas L Veiler, Thomas Terp Paulsen, Carsten Kegler, Camilla Bak Nielsen, Mogens Johannsen, Thomas Bjørnskov Poulsen, Helge B. Bode, Thomas Tørring

This study reconstitutes the APD biosynthesis pathway in E. coli to identify the PKS machinery responsible for warhead formation.

bioRxiv · Sep 23, 2026 · PreprintBiochemistry

Site-Specific Introduction of Non-Canonical Amino Acids into natural and engineered Non-Ribosomal Peptides

Max Schreiber, Maryam Dehghan, Shadrack Kibet, Marie Tvilum, Carsten Kegler, Kevin Hoffmann, Peter Grün, Sven Balluff, Karsten Siems, Helge B. Bode

The paper introduces non-canonical amino acids into non-ribosomal peptides by engineering NRPS systems and performing post-enzymatic chemical synthesis in bacterial culture extracts.

bioRxiv · Jul 13, 2026 · PreprintBiochemistry

Evolution Inspired Engineering of Megasynthetases

Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler, Sebastian Kaiser, Yan‐Ni Shi, Wolfgang Kuttenlochner, Leonie Schenk, T. M. Mohiuddin, M. Groll, Georg K. A. Hochberg, Helge B. Bode

The paper describes an evolution-inspired method to engineer NRPS by identifying a recombination breakpoint and using it to assemble NRPS fragments for producing a proteasome inhibitor.

bioRxiv · Dec 2, 2022 · PreprintSynthetic Biology