Massimo Cavallaro

This study investigates the role of SETD2 and H3K36me3 in transcriptional dynamics by analyzing gene expression and splicing in murine C2C12 myoblast cells following their depletion.

The paper estimates how many new phage species can be discovered based on existing databases and identifies changes in species abundance over time.

The paper introduces TV-PRO-seq to measure polymerase pausing times at single-base resolution and finds that pausing is more frequent but shorter near promoters, with longer pauses in highly expressed genes.

The paper measures transcriptional bursting using Bayesian methods and shows that polymerase shuttling affects burst size and frequency, with implications for transcriptional noise.