Daniel Hebenstreit

This study investigates the role of SETD2 and H3K36me3 in transcriptional dynamics by analyzing gene expression and splicing in murine C2C12 myoblast cells following their depletion.

This study shows that immune cell steroidogenesis is essential for resolving inflammation and promoting recovery in acute lung injury.

The paper introduces a Bayesian model to analyze 4sU scRNA-seq data, improving inference of transcriptional bursting parameters and their relationship with histone modifications.

The paper investigates the degradation mechanisms of non-capped mRNAs by depleting capping enzymes in yeast, revealing that Xrn1 buffers mRNA levels and protects against 5-3 degradation.

This study identifies CMTr1 and CMTr2 as cap-adjacent 2'-O-ribose methyltransferases essential for reward learning and synaptic mRNA localization in Drosophila.

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

This study identifies RPRD proteins as negative regulators of transcription in human cells, showing their inverse correlation with RNA accumulation and their role in forming complexes with Pol II.

The paper introduces TV-PRO-seq to measure polymerase pausing times at single-base resolution and finds that pausing is more frequent but shorter near promoters, with longer pauses in highly expressed genes.

The paper measures transcriptional bursting using Bayesian methods and shows that polymerase shuttling affects burst size and frequency, with implications for transcriptional noise.

The paper investigates how non-coding RNAs from the Prader-Willi syndrome locus regulate gene expression in human iPSCs, showing their role in neurodevelopmental processes.