Christopher L. Mendias

Germline-mediated ubiquitous recombination in ScxCre male mice: implications for tendon research

The paper shows that ScxCre mice cause unintended recombination in male germline, leading to global gene effects in offspring, and advises sex selection to avoid off-target effects.

Increased Ca2+ signaling through CaV1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties

This study shows that increased CaV1.2 Ca2+ signaling in tendon fibroblasts leads to tendon hypertrophy, increased collagen fibrillogenesis, and improved biomechanical properties.

Widespread diversity in the transcriptomes of functionally divergent limb tendons

This study creates a transcriptomic atlas of limb tendons in mice and rats, revealing significant transcriptome diversity within and across species.