Alayna E. Loiselle

Loss of Cochlin drives impairments in tendon structure and function

This study shows that loss of Cochlin leads to structural and functional impairments in tendons, highlighting its role in maintaining tendon homeostasis.

Pharmacological Antagonism of Ccr2+ Cell Recruitment to Facilitate Regenerative Tendon Healing

This study shows that temporarily blocking Ccr2+ cell recruitment during the late inflammatory/early proliferative phase improves tendon healing mechanics, while blocking during the acute phase has no effect.

Increased Ca2+ signaling through CaV1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties

This study shows that increased CaV1.2 Ca2+ signaling in tendon fibroblasts leads to tendon hypertrophy, increased collagen fibrillogenesis, and improved biomechanical properties.

Defining the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing by combining lineage tracing and spatial transcriptomics

This study combines lineage tracing and spatial transcriptomics to define the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing, identifying key molecular regions and their roles in healing.

Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

This study shows that suppressing IKKβ/NF-κB in Scleraxis-lineage cells during tendon healing increases scar tissue and apoptosis.