Alessandra Raspanti

This study shows that CDKL5 deficiency in mice leads to sensory processing defects in the barrel cortex and autistic traits, which can be rescued by neonatal CDKL5 replacement.

The paper investigates how spontaneous activity guides the development of multisensory integration in the developing higher-order cortex by establishing co-aligned topographic projections.

This study shows that mGluR5 positive-allosteric modulators correct synaptic and behavioural defects in a CDKL5 deficiency disorder mouse model and human patients.