Giulia Sagona

This study shows that CDKL5 deficiency in mice leads to sensory processing defects in the barrel cortex and autistic traits, which can be rescued by neonatal CDKL5 replacement.

This study uses pupillometry and whole-brain c-Fos mapping to show that emotional contagion in mice involves shared neural activation and multisensory processing.

This study shows that mGluR5 positive-allosteric modulators correct synaptic and behavioural defects in a CDKL5 deficiency disorder mouse model and human patients.

This study shows that gut microbiota changes in enriched environment mice regulate visual cortical plasticity through short-chain fatty acids.

MEYE is a web app using a Convolutional Neural Network to perform real-time pupillometry in mice and humans, offering a simple and accessible tool for non-specialists.

This study shows that using a secretable TATk-CDKL5 protein in AAV gene therapy improves CDKL5 replacement and functional outcomes in Cdkl5 KO mice compared to native CDKL5 expression.