Condensate-Driven Triglyceride Depletion Links alpha-Synuclein to Mitochondrial Dysfunction
Tao Zhang, María Eugenia Goya, Alejandro Herrón-Bedoya, Jorien C. van der Weerd, Dikaia Tsagkari, Suzanne Couzijn, Lale Güngördü, Renée I. Seinstra, Margaretha Rebecca Heiner-Fokkema, Ming Chang, Nektarios Tavernarakis, Folkert Kuipers, Ellen A. A. Nollen
This study shows that alpha-synuclein condensation disrupts lipid metabolism, reduces triacylglycerols, and impairs mitochondrial function in C. elegans, with potential therapeutic implications for Parkinson's disease.
bioRxiv · Oct 22, 2025 · PreprintCell Biology