Nektarios Tavernarakis

This study identifies a PPARγ-like signaling pathway in C. elegans that links lipid metabolism and mitochondrial quality control to maintain neuronal function.

MORPHIS quantifies single-cell morphological responses to treatments and aging, distinguishing compound-specific signatures and aging-related changes in Caco-2, HeLa, and C. elegans cells.

This study shows that alpha-synuclein condensation disrupts lipid metabolism, reduces triacylglycerols, and impairs mitochondrial function in C. elegans, with potential therapeutic implications for Parkinson's disease.