DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80
Philippe Frit, Himani Amin, Sayma Zahid, Nadia Barboule, Chloe Hall, Gurdip Matharu, Steven W. Hardwick, Jeanne Chauvat, Sébastien Britton, Dimitri Y. Chirgadze, Virginie Ropars, Jean‐Baptiste Charbonnier, Patrick Calsou, Amanda K. Chaplin
This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.
Nature Communications · May 6, 2025Peer-reviewedBiochemistry