Jean‐Baptiste Charbonnier

Structural basis for continuous DNA-end protection during ligation of double-strand breaks in yeast Non-Homologous End-Joining

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

Restriction on Ku's Inward Translocation Caps Telomere Ends

The paper reveals that Rap1 inhibits Ku's NHEJ function at telomeres by obstructing Ku's inward translocation, preventing promiscuous repair.

Ku-binding motifs in RAG2, XLF, PAXX and MRI support functional redundancy during V(D)J recombination

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading

This study identifies the FIGNL1-FIRRM complex as essential for completing meiotic recombination in mice by regulating RAD51 and DMC1 loading, independent of DNA damage.

Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation

The paper identifies the role of the MutLγ-Exo1 complex in meiotic crossover formation by showing Exo1 recruits Cdc5 to activate MutLγ and highlights its spatial regulation near DSB hotspots.