Virginie Ropars

Structural basis for continuous DNA-end protection during ligation of double-strand breaks in yeast Non-Homologous End-Joining

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

Molecular and functional dissection of the AP2-I/BDP1 transcriptional complex of the malaria parasite reveals a role beyond the red blood cell stages

This study identifies the AP2-I/BDP1 transcriptional complex in malaria parasites, showing its role in blood stage development and sexual commitment, with potential as a drug target.

DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

Restriction on Ku's Inward Translocation Caps Telomere Ends

The paper reveals that Rap1 inhibits Ku's NHEJ function at telomeres by obstructing Ku's inward translocation, preventing promiscuous repair.

Ku-binding motifs in RAG2, XLF, PAXX and MRI support functional redundancy during V(D)J recombination

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading

This study identifies the FIGNL1-FIRRM complex as essential for completing meiotic recombination in mice by regulating RAD51 and DMC1 loading, independent of DNA damage.