Author

Karen I. Lange

University College DublinORCID 0000-0002-2414-5277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Oliver E. BlacqueiD· 3 shared Colin A. JohnsoniD· 2 shared Sofia TsiropoulouiD· 2 shared Sunayna K. BestiD· 2 shared Gregory J. PazouriD· 1 shared Ian Berry· 1 shared Karyn L. RobertiD· 1 shared Katarzyna KucharskaiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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3 shared papersGenetics

Oliver E. BlacqueORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 16, 2025

Synthetic guide sequence to generate CRISPR-Cas9 entry strains in C. elegans

The paper introduces a synthetic CRISPR guide sequence for generating entry strains in C. elegans when the standard dpy-10 guide is unsuitable.

1 citation

C. elegansCRISPR screen

𝕏 PostBluesky

Cell BiologyNature CommunicationsPeer-reviewedMay 28, 2025

Two functional forms of the Meckel-Gruber syndrome protein TMEM67 generated by proteolytic cleavage by ADAMTS9 mediate Wnt signaling and ciliogenesis

Manu Ahmed, Sydney Fischer, Karyn L. Robert…·Sumeda Nandadasa

9 citations

humanC. elegans

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 17, 2021

Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in an animal model

Karen I. Lange, Sunayna K. Best, Sofia Tsiropoulou…·Oliver E. Blacque

This study uses C. elegans to interpret the pathogenicity of ciliopathy-associated missense VUS by testing their functional impact on sensory cilia.

DOI 10.1101/2021.06.17.448799

C. elegansexperimental assay

𝕏 PostBluesky

GeneticsDisease Models & MechanismsPeer-reviewedNov 24, 2020

Interpreting the pathogenicity of Joubert Syndrome missense variants in Caenorhabditis elegans

Karen I. Lange, Sofia Tsiropoulou, Katarzyna Kucharska, Oliver E. Blacque

This study uses C. elegans to analyze pathogenic missense variants in B9D2/mksr-2 associated with Joubert Syndrome, showing their impact on ciliary structure and function.

26 citations

C. elegansexperimental assay

𝕏 PostBluesky