Sumeda Nandadasa

This study shows ADAMTS9 deletion in mice causes polycystic kidney disease by disrupting ciliogenesis and collagen homeostasis, leading to small, cystic kidneys and early lethality in males.

This study shows that Ift43 regulates Gli2 and Gli3 levels in cilia, affecting Hedgehog signaling and causing developmental defects in mice.

This study identifies the versican-hyaluronan complex as essential for vasculogenesis and primitive hematopoiesis by providing a niche for Flk1+ progenitors during gastrulation.

The paper identifies differential proteoglycan dynamics in umbilical artery and vein as the mechanism ensuring rapid arterial closure and venous patency at birth.