Yue Wan

RNAverse, a multimodal generative model, designs functional RNAs with high performance across tasks, outperforming existing methods and enabling applications in gene therapy and vaccine development.

This paper introduces an AI framework to improve mRNA therapeutic manufacturing by predicting and optimizing sequence design for in vitro transcription efficiency.

The paper uses single-molecule RNA structure probing to study how RNA structural heterogeneity affects the heat shock response in C. albicans.

The paper investigates how RNA structure influences stress granule formation and recovery, showing that single-stranded RNA is preferentially included in stress granules and that RNA-binding proteins and helicases regulate this process.

This study benchmarks Nanopore long read RNA sequencing in human cell lines, showing improved isoform resolution compared to short reads.

The paper identifies an RNA regulon involving the 3UTR of FurinA and Ybx1 that regulates translational repression, essential for heart morphogenesis and valve function in zebrafish.

This study examines RNA structure changes during human neurogenesis and their role in gene regulation, finding that RNA structure dynamics are linked to translation, decay, and regulatory mechanisms involving RBPs and miRNAs.

This study maps SARS-CoV-2 RNA interactions in vivo, identifying structural elements and host RNA interactions that may contribute to viral pathogenicity.

This paper introduces a capture-based method to purify whole viral native RNA genomes, achieving high purification and mapping efficiency in direct RNA sequencing.

This study maps the structural interactions of dengue and Zika viruses, identifying functional long-range interactions and their role in viral replication and attenuation.