Roland G. Huber

This study shows that combining phages targeting both encapsulated and capsule-deficient Klebsiella pneumoniae strains improves bacterial suppression and antibiotic susceptibility.

RNAverse, a multimodal generative model, designs functional RNAs with high performance across tasks, outperforming existing methods and enabling applications in gene therapy and vaccine development.

This study evaluates three docking programs for RNA-ligand screening, finding similar overall performance but differences across RNA classes and chemotypes, suggesting tailored scoring strategies could improve virtual screening.

This study investigates how the DENV capsid protein interacts with single-stranded DNA, revealing structural changes that suggest molecular condensation and potential phase separation in complex formation.

This paper introduces an AI framework to improve mRNA therapeutic manufacturing by predicting and optimizing sequence design for in vitro transcription efficiency.

The paper introduces HomRank, a ranking method for RNA 3D structure assessment that improves accuracy over existing methods on benchmark datasets.

The paper investigates how RNA structure influences stress granule formation and recovery, showing that single-stranded RNA is preferentially included in stress granules and that RNA-binding proteins and helicases regulate this process.

This study examines RNA structure changes during human neurogenesis and their role in gene regulation, finding that RNA structure dynamics are linked to translation, decay, and regulatory mechanisms involving RBPs and miRNAs.

This study maps SARS-CoV-2 RNA interactions in vivo, identifying structural elements and host RNA interactions that may contribute to viral pathogenicity.

The paper maps the genome-wide association of capsid proteins with viral RNA in Dengue and Zika viruses, showing non-uniform binding patterns and sequence preferences.

This study maps the structural interactions of dengue and Zika viruses, identifying functional long-range interactions and their role in viral replication and attenuation.